The new Covid vaccine from MIT solves two problems at once.
First, it is a traditional vaccine, using dead virus, or at least parts of the dead virus that have been removed from the viral capsule. (In this case, the spike protein).
Second, it uses a scaffolding of DNA to prevent the cytokine storm from the immune reaction. The DNA is structured to "mimic" an intact virus, but does not elicit an immune response by itself.
Technically this invention is a new form of "particulate vaccine". It requires knowledge of the antigen conformation in advance. Which, in the case of Covid, was known 30 days after the outbreak.
First, it is a traditional vaccine, using dead virus, or at least parts of the dead virus that have been removed from the viral capsule. (In this case, the spike protein).
Second, it uses a scaffolding of DNA to prevent the cytokine storm from the immune reaction. The DNA is structured to "mimic" an intact virus, but does not elicit an immune response by itself.
Technically this invention is a new form of "particulate vaccine". It requires knowledge of the antigen conformation in advance. Which, in the case of Covid, was known 30 days after the outbreak.
DNA particles that mimic viruses hold promise as vaccines
Using a DNA-based delivery particle, researchers created a vaccine that can induce a strong antibody response against SARS-CoV-2.
news.mit.edu