A German team of researchers this week said they may have discovered what causes rare blood clots in some COVID-19 vaccine recipients.
Rolf Marschalek, a professor at Goethe University in Frankfurt who has been involved in studies looking into the rare clotting condition caused by the Oxford-AstraZeneca vaccine, said his researcher showed the issue may be triggered due to adenovirus vectors.
An adenovirus—a common cold virus that can’t replicate—is the primary mechanism used by both the AstraZeneca and Johnson & Johnson vaccines, delivering the genetic instructions for the spike protein of the virus into the recipient’s body. Meanwhile, vaccines made by Moderna and Pfizer use mRNA technology.
The German scientists led by Marschalek said in a research paper that hasn’t yet been peer-reviewed that the problem might be caused when the adenovirus enters the nucleus of the cell rather than the cellular fluid, where the virus makes proteins.
“The adenovirus life cycle includes the infection of cells … entry of the adenoviral DNA into the nucleus, and subsequently gene transcription by the host transcription machinery,” they wrote, reported The Guardian. “And exactly here lies the problem: the viral piece of DNA … is not optimized to be transcribed inside of the nucleus.”
Marschalek told The Financial Times that mRNA-based vaccines deliver the protein spike’s genetic material into the cell fluid, saying it never goes into the nucleus.
p>“When these … virus genes are in the nucleus they can create some problems,” Marschalek said. Vaccines using adenovirus, he added, can be redesigned to avoid the problem in the future.
Johnson & Johnson “is trying to optimize its vaccine now,” he told Financial Times. “With data we have in our hands we can tell the companies how to mutate these sequences, coding for the spike protein in a way that prevents unintended splice reactions.”
(Excerpt) Read more at theepochtimes.com
You may want to watch this site for more info!
https://www.algora.com/Algora_blog/2021/03/16/mit-harvard-study-suggests-mrna-vaccine-
Rolf Marschalek, a professor at Goethe University in Frankfurt who has been involved in studies looking into the rare clotting condition caused by the Oxford-AstraZeneca vaccine, said his researcher showed the issue may be triggered due to adenovirus vectors.
An adenovirus—a common cold virus that can’t replicate—is the primary mechanism used by both the AstraZeneca and Johnson & Johnson vaccines, delivering the genetic instructions for the spike protein of the virus into the recipient’s body. Meanwhile, vaccines made by Moderna and Pfizer use mRNA technology.
The German scientists led by Marschalek said in a research paper that hasn’t yet been peer-reviewed that the problem might be caused when the adenovirus enters the nucleus of the cell rather than the cellular fluid, where the virus makes proteins.
“The adenovirus life cycle includes the infection of cells … entry of the adenoviral DNA into the nucleus, and subsequently gene transcription by the host transcription machinery,” they wrote, reported The Guardian. “And exactly here lies the problem: the viral piece of DNA … is not optimized to be transcribed inside of the nucleus.”
Marschalek told The Financial Times that mRNA-based vaccines deliver the protein spike’s genetic material into the cell fluid, saying it never goes into the nucleus.
p>“When these … virus genes are in the nucleus they can create some problems,” Marschalek said. Vaccines using adenovirus, he added, can be redesigned to avoid the problem in the future.
Johnson & Johnson “is trying to optimize its vaccine now,” he told Financial Times. “With data we have in our hands we can tell the companies how to mutate these sequences, coding for the spike protein in a way that prevents unintended splice reactions.”
(Excerpt) Read more at theepochtimes.com
You may want to watch this site for more info!
https://www.algora.com/Algora_blog/2021/03/16/mit-harvard-study-suggests-mrna-vaccine-
