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I remember a time when stores in San Francisco had a huge variety of mushrooms for sale and not all were for culinary arts. Now, there is a claim that certain ones contain something to help cure depression. I also seem to remember that some of those wandering around Haight/Ashbury certainly seemed far from depressed to me.
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Anyhow, read about this medical advance @ Compound in Magic Mushrooms Could Treat Depression - D-brief | DiscoverMagazine.com