COVID-19’s Biological Politics

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Ritonavir inhibits CYP2D6. These drug interactions are not well documented:

Jun 2021 CYP2D6 Coronavirus

Lopinavir-Ritonavir in SARS-CoV-2 Infection and Drug-Drug Interactions with Cardioactive Medications - PubMed

Lopinavir-ritonavir combination is being used for the treatment of SARS-CoV-2 infection. A low dose of ritonavir is added to other protease inhibitors to take advantage of potent inhibition of cytochrome (CYP) P450 3A4, thereby significantly increasing the plasma concentration of coadministered...

pubmed.ncbi.nlm.nih.gov

’....Ritonavir inhibits CYP2D6....Many cardiology, pulmonology, and intensivist physicians have never been exposed to clinical scenarios requiring co-prescription of cardiac and antiviral therapies.’

Oct 2020 Spain: CYP2D6 / SARS-CoV / Loss-of-Function

Towards Accurate Genotype-Phenotype Correlations in the CYP2D6 Gene - PubMed

Establishing accurate and large-scale genotype-phenotype correlations and predictions of individual response to pharmacological treatments are two of the <i>holy grails</i> of Personalized Medicine. These tasks are challenging and require an integrated knowledge of the complex processes that...

pubmed.ncbi.nlm.nih.gov

 

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#539: These viruses are already bioweapons before being brought into the lab, at which point two populations of the virus are created.

#540: In all likelihood, Shi Zheng-Li started the conspiracy. Anderson, working at Wuhan with a filovirus such as ebola, would know about the Chinese filovirus, Mengla, discovered in Mengla County in 2019, from the same bat genus that is reservoir of Marburg filovirus in Africa: Rousettus.

 

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CYP2D6 Coagulopathies

We’ll select one of the authors of the ‘Interethnic Differences‘ report (post #538) to link thromboembolism-CYP2D6. Nguyen is also a Wisconsin author:

Nguyen AT, et al
Tamoxifen-Induced Hot Flashes / CYP2D6

Association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort - PubMed

Women with reduced CYP2D6 activity have low endoxifen concentrations and likely worse long term benefits from tamoxifen. We investigated the association between CYP2D6 genotype and tamoxifen-induced hot flashes in a prospective cohort. We collected hot flash frequency and severity data over 12...

pubmed.ncbi.nlm.nih.gov

’....Intermediate metabolizers had greater mean hot flash scores after 4 months of tamoxifen therapy.....Conflicts of Interest: NLH received research funding from Astrazeneca; JMR has received research funding From Pfizer....’

Nguyen AT, et al
Thromboembolism / CYP2D6 / Tamoxifen

Estrogen receptor genotype is associated with risk of venous thromboembolism during tamoxifen therapy - PubMed

Thromboembolism is a serious complication of tamoxifen therapy in women with breast cancer. Banked DNA from tamoxifen-treated individuals with breast cancer from the Marshfield Clinic Personalized Medicine Research Project, a population-based DNA repository, was tested for association between...

pubmed.ncbi.nlm.nih.gov

The Spanish report above (Oct 2020) states:

’Despite the inherent complexity in establishing genotype-phenotype correlations in the CYP2D6 gene, a simple phenotypic score was proposed in 2008 that qualitatively ranked the phenotype (i.e., poor, intermediate, extensive-normal or ultrarapid metabolizers) by assigning a given value for each allele, including activity enhancement due to gene duplications....This gene could be more generally useful for the accurate prediction of these genotype-phenotype correlations (particularly for missense mutations) on a genome-wide scale, and the implications for individual response to pharmacological treatments, one of the holy grails of Personalized Medicine.’

We will link these things back to FIPV infection in Trichosurus and the Antley-Bixler syndrome in humans for further comparison of CYP2D6 genetics.

 

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To link morphine to tamoxifen will bring more into focus, CYP2D6 in Southeast Asia linking influences in viral infections such as opioid addiction and HIV-1:

Tamoxifen / Morphine

Unveiling the Impact of Morphine on Tamoxifen Metabolism in Mice in vivo - PubMed

<span><b>Background:</b> Tamoxifen is used to treat breast cancer and cancer recurrences. After administration, tamoxifen is converted into two more potent antitumor compounds, 4OH-tamoxifen and endoxifen by the CYP3A4/5 and 2D6 enzymes in human. These active compounds are inactivated by the...

pubmed.ncbi.nlm.nih.gov

’....Mouse liver microsomes were used to determine the impact of morphine on 4OH-tamoxifen metabolism in vitro.’

’P450 oxidoreductase (POR) is an electron-transport flavoprotein required for the catalytic activities of all microsomal (but not mitochondrial) cytochrome P450 enzymes. The 50 distinct cytochrome P450 enzymes are involved in the biosynthesis of steroid hormones, prostaglandins, bile acids, leukotrienes, vitamin D, retinoids, and other molecules, as well as in the hepatic metabolism of drugs and xenobiotics.’
(Miller WL, P450 Oxidoreductase Deficiency and the Antley-Bixler Syndrome, in Epstein, Inborn Errors of Development, Ch. 179)

 

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Shown on the Jinghong map will be links to Dali, Pu’er, Tongguan, and Mengla in Yunnan Province. We mentioned Dali on 19 Feb 2020 in the snake meat thread, post #467, that linked Wuhan Institute of Virology:

Post #467

Snake Meat......source of chinese virus

Iwata explains in a video in the report (post #460) which states at timepoint 4:15 ' "There was no distinction between the green zone which is free of infection and the red zone....(@5: 56) I never had fear...." '

www.usmessageboard.com

’....2.) Bat SARS-like Coronavirus Rf 4092 Eco Health Alliance, New York; Yunnan Institute of Endemic Diseases, Dali; Dali University, Dali; Wuhan Institute of Virology.’

Jinghong Map of Yunnan

Jinghong

Jinghong is the capital of Xishuangbanna in southern Yunnan. Jinghong has about 643,000 residents. Mapcarta, the open map.

mapcarta.com

Pu’er is NNE of Jinghong. Mengla is ESE of Jinghong. Tongguan (SARS-CoV-2’s closest relative) is on Route G213 (G8511 Expressway), NE of Pu’er.

Linking back to CYP2D6 previously, we’ll look closer at the amino acids involved in these mutations:

Vivax Malaria / Pu’er, Yunnan / Dali University, Yunnan / CYP2D6 Mutations

The association of CYP2D6 gene polymorphisms in the full-length coding region with higher recurrence rate of vivax malaria in Yunnan Province, China - PubMed

Mutation of CYP2D6*10 allele accounts for the highest proportion of vivax malaria cases in Yunnan Province. The mutations of c. 886C > T and CYP2D6*2 allele, which correspond to impaired PQ metabolizer phenotype, are most closely related to the relapse of vivax malaria. In addition, the genotype …

pubmed.ncbi.nlm.nih.gov

 

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How the Delta variant does in Russian hosts will be especially interesting, because Putin has revealed he has taken the adenovirus-vectored vaccine:

3 hours ago, Moscow Times Coronavirus in Russia

Coronavirus in Russia: The Latest News | Feb. 24 - The Moscow Times

Russia has confirmed 18,315,292 cases of coronavirus and 378,784 deaths, according to the national coronavirus information center. Russia’s total excess fatality count since the start of the coronavirus pandemic is at least 995,000. Under half the population is fully vaccinated.

www.themoscowtimes.com

’....Putin said Wednesday that he was vaccinated against the coronavirus with Russia’s Sputnik V jab, lifting the veil on a months-long secret that did little to quell Russians’ vaccine hesitancy....25 June Russia is investigating reports of the first Delta Plus variant infections within its borders, the country’s consumer protection watchdog told state-run RIA Novosti on Friday....18 Jun nearly 90% of Moscow’s new infections are the Delta variant, said Mayor Sobyanin.’

 

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It appears that the Delta variant is a pandemic of the unvaccinated:

27 Jun 2021 LA Times: Delta Variant U.S. (California)

Highly contagious Delta coronavirus variant spreading fast in California

The Delta variant now makes up 14.5% of coronavirus cases analyzed so far this month in California, up from 4.7% in May.

www.latimes.com

’....Pfizer-BioNTech vaccine was 88% effective against symptomatic disease caused by the Delta variant and 96% protective against hospitalization.’

 

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Via video, Putin answers questions from citizens about COVID-19 and vaccinations:

30 Jun 2021 Novaya Gazeta

ÐÑÑÐ¼Ð°Ñ Ð»Ð¸Ð½Ð¸Ñ ÐÑÑина во вÑÐµÐ¼Ñ ÑÑеÑÑей Ð²Ð¾Ð»Ð½Ñ ÐºÐ¾Ð²Ð¸Ð´Ð°. ТекÑÑÐ¾Ð²Ð°Ñ ÑÑанÑлÑÑÐ¸Ñ Ð´Ð¸Ð°Ð»Ð¾Ð³Ð° пÑезиденÑа Ñ ÑоÑÑиÑнами â ÐÐ¾Ð²Ð°Ñ Ð³Ð°Ð·ÐµÑа

18-я по счету Прямая линия президента России Владимира Путина проходит в Центре международной торговли в Москве. Ведущие мероприятия — Наиля Аскер-заде («Россия») и Екатерина Березовская (Первый канал). Самые популярные вопросы от россиян к президенту, как сообщал редактор Прямой линии Антон...

novayagazeta.ru

’....
Eshche odin vopros pro vaktsinatsiiu
Another Question About Vaccination

Videovopros is Moskvy of Ekateriny:
Video Question from Moscow from Ekaterina:

“Ia planirovala poluchit vaktsinu, no, k sozhaleniiu, v punktakh vaktsinatsii vrachi ne smogli otvetit’ na vopros, ne iavliaiutsia li protivopokazaniiami moi zabolevaniia.
I was planning to receive a vaccine, but unfortunately, at the vaccination points, the doctors could not answer the question if my diseases were contraindications.

Gde mozhno poluchit’ kvalifitsirovannuiu pomoshch’ i otvety na moi voprosy?
Where can I get qualified help and answers to my questions?”

Vladimir Putin:

“Otvet prostoi.
The answer is simple.

Esli u vas est’ kakie-to zabolevvaniia, khronicheskie, to naverniaka vy obshchaetes’ s vrachom-spetsialistom, kotoryi vas vedet.
If you have any diseases, chronic, then for sure you are talking with a specialist doctor who is leading you.

V privivochnykh punktakh mogut ne skazal.
At the vaccination stations, they may not say.

Kto tam rabotaet?
Who works there?

Medsestry.
Nurses.

A rech’ idet ob uzkikh spetsialistakh, k nim nuzhno obratit’sia.
And we are talking about, narrow specialists, you need to contact them.”
....
“ I vam rekomenduiu!” Putin rasskazal, chto privilsia “Sputnikom V.”
”And I recommend it to you!” Putin said that he took “Sputnik V.”

Vooruzhennye sily privivaiutsia etoi vaktsinoi, a ia vse-taki Verkhovnyi glavnokomanduiushchi,” otmetil on.
The armed forces are vaccinated with this vaccine, but I am still the Supreme Commander-in-Chief,” he said.

Pri etom Putin skazal, chto pochti ne sovetovalsia s vrachami, a smotrel, kakoi preparat vybiraiut znakomye.
At the same time, Putin said that he almost did not consult with doctors, but watched which drug his friends were choosing.

Po dannym presidenta, uzhe vaktsinirovany svyshche 20 mil rossiian.
According to the president, over 20 million Russians havve already been vaccinated.

On takzhe uveril, chto ot rossiiskikh vaktsin net takikh posledstvii, kak ot “AstraZeneki” ili “Pfaizera.”
He also assured that therre are no such consequences from Russian vaccines as from AstraZeneca or Pfizer.’

 

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Comparison of vaccines, such as Sputnik V, which uses two different adenovirus vectors, and AstraZeneca, which uses a chimpanzee adenovirus, this report from Izvestia on Pfizer and Moderna:

26 Jun 2021 Izvestia

Фармрегулятор США расширил предупреждения к вакцинам Pfizer и Moderna

iz.ru

Farmregulator SShA rashiril preduprezhdeniia k vaktsinam Pfizer i Moderna
US Pharmaceutical Regulator Expands Warnings for Pfizer and Moderna Vaccines
....
Reguliator otmechaet risk vospaleniia serdtsa posle vaktsinatsii ukazannymi preparatami.
The regulator notes the risk of heart inflammation after vaccination with these drugs
....
povyshennogo riska miokardita (vospalenie serdechnoi myshtsy) i perikardita (vospalenie tkani, okruzhaiushchei serdtse) posle vaktsinatsii.
due to perceived risk of myocarditis (inflammation of the heart muscle) and pericarditis (inflammation of the tissues surrounding the heart) following vaccination.’

 

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AstraZeneca vaccine uses chimpanzee adenovirus as a vector, and France refused it earlier:

10 May 2021 Frantsiia otkazhetsia ot AstraZeneca protiv novykh shtammov
France Will Not Use AstraZeneca Vaccine Against New Strains

Франция не будет использовать вакцину AstraZeneca против новых штаммов

Франция откажется от AstraZeneca против новых штаммов коронавируса. С возбудителем будут бороться вакцинами от других фирм, сообщает телеканал «Известия». Официальное заявление сделал глава Пятой республики Эммануэль Макрон. Ранее Еврокомиссия не продлила контракт с AstraZeneca на второе...

iz.ru

’....
Evrochinovniki podali v sud na farmatsevtov.
European officials filed a lawsuit against pharmacists.’

 

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A few points are necessary for Russian Sputnik V vaccine before making the link to ebola and other filoviruses:

1 Jul 2021 Sputnik V. Vse o pervoi rossiiskoi vaktsine ot koronavirusa
All About the First Russian Vaccine Against Coronavirus

"Спутник V". Все о первой российской вакцине от коронавируса

Гам-КОВИД-Вак", известная также как "Спутник V", — первая зарегистрированная в мире вакцина для профилактики COVID-19. По оценкам разработчиков, препарат... РИА Новости, 02.07.2021

ria.ru

V vaktsine ispol’zuiut vektor na osnove dvvukh raznykh shtammov adenovirusa cheloveka - 26go i piatgogo serotipa (Ad26, Ad5)
The vaccine uses a vector based on two different strains of human adenovirus — serotypes 26 and 5.
....
V mire est’ neskol’ko vektornykh vaktsin ot koronavirusa.
There are several vector vaccines for coronavirus in the world.

Naprimer, amerikanskaia kompaniia Johnson & Johnson sozdala preperat na osnove adenovirusa cheloveka Ad26, a kitaiskaia CanSino Biologics — Ad5.
For example, the American company Johnson & Johnson created a drug based on the human adenovirus Ad26, and the Chinese CanSino Biologics — ad5.

Obe vvodiat odnokratno.
Both are administered once.
....
Unikal’nost’ i vtoroi dozakh ispol’zovany raznye virusnye vektory - snachala Ad26, zatem Ad5.
The uniqueness of the Russian technology is that different viral vectors are used in the first and second doses - first Ad26, then Ad5.

Pri takoi skheme obshche uroven’ immunizatsii namnogo vyshe.
With this scheme, the overall level of immunization is much higher.

Eshche odnu vektornuiu vaktsinu razrabotala anglo-shvedskaia kompaniia, AstraZeneca.
Another vector vaccine was developed by the Anglo-Swedish company AstraZeneca.

Odnako v nei v kachestve vektora ispol’zuiut adenovirus shimpanze.’
However, it uses chimpanzee adenovirus as a vector.

 

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One important thing the reader can do is to memorize the mutations that comprise the Delta variant, because some of them occur in other variants, while others do not:

1 Jul 2021 Delta Variant Surges Worldwide

As Delta Variant Surges, Outbreaks Return in Many Parts of the World

The nightmare is returning. In Indonesia, grave diggers are working into the night, as oxygen and vaccines are in short supply. In Europe, countries are slamming their doors shut once again, with quarantines and travel bans. In Bangladesh, urban garment workers fleeing an impending lockdown are...

www.yahoo.com

 

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One link to adenovirus 26, ebola and the filoviruses is here:

May 2021 Germany, Korea, UK:, Janssen Pharmaceuticals, Titusville, N.J.; Brighton Collaboration, Decatur, Ga.; University of Florida at Gainesville: Ad26 ZEBOV/MVA-BN-Filo

Immunogenicity of Ad26.COV2.S vaccine against SARS-CoV-2 variants in humans - PubMed

The Ad26.COV2.S vaccine^1-3 has demonstrated clinical efficacy against symptomatic COVID-19, including against the B.1.351 variant that is partially resistant to neutralizing antibodies¹. However, the immunogenicity of this vaccine in humans against SARS-CoV-2 variants of...

pubmed.ncbi.nlm.nih.gov

(2012) Leiden, The Netherlands: Ad35 & Ad26 Responses to Multiple Filovirus Species

Ad35 and ad26 vaccine vectors induce potent and cross-reactive antibody and T-cell responses to multiple filovirus species - PubMed

Filoviruses cause sporadic but highly lethal outbreaks of hemorrhagic fever in Africa in the human population. Currently, no drug or vaccine is available for treatment or prevention. A previous study with a vaccine candidate based on the low seroprevalent adenoviruses 26 and 35 (Ad26 and Ad35)...

pubmed.ncbi.nlm.nih.gov

No doubt that Mengla filovirus previously mentioned, has been tested in animals.

Influenza virus recognizes sialic acid:

Influenza Recognizes Sialic Acid

Influenza A viruses use multivalent sialic acid clusters for cell binding and receptor activation - PubMed

Influenza A virus (IAV) binds its host cell using the major viral surface protein hemagglutinin (HA). HA recognizes sialic acid, a plasma membrane glycan that functions as the specific primary attachment factor (AF). Since sialic acid alone cannot fulfill a signaling function, the virus needs to...

pubmed.ncbi.nlm.nih.gov

Sep 2019 Human Adenovirus Type 26 Uses Sialic Acid-Bearing Glycans As Primary Cell Entry Receptor

Human adenovirus type 26 uses sialic acid-bearing glycans as a primary cell entry receptor - PubMed

Adenoviruses are clinically important agents. They cause respiratory distress, gastroenteritis, and epidemic keratoconjunctivitis. As non-enveloped, double-stranded DNA viruses, they are easily manipulated, making them popular vectors for therapeutic applications, including vaccines. Species D...

pubmed.ncbi.nlm.nih.gov

’....We observe complete conservation of Tyr314 and Lys349 across the four types and conservation of Asp312 with HAdV-D8.’

With the addition of asparagine (N), the SARS-CoV-2 mutation @ 417 is interesting to compare for the P.1 Brazil-Japan variant, originally published as K417N/T, as if the virus was imitating HAdV-D8.

 

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We think that the reason the CDC changed its webpage for the P.1 Brazil-Japan variant mutation, K417N/T to K417T (removing the N), even though P.1 also has a T20N mutation, was due to its link to Japanese adenovirus outbreaks:

Japan / HAdV-D8 Outbreak

Adenoviral Infections in Singapore: Should New Antiviral Therapies and Vaccines Be Adopted? - PubMed

Singapore would benefit from more frequent studies of clinical HAdV genotypes to identify patients at risk for severe disease and help guide the use of new antiviral therapies, such as brincidofovir, and potential administration of HAdV 4 and 7 vaccine.

pubmed.ncbi.nlm.nih.gov

’....HAdV-D8, -D54, and -C2 (Japan)....’

 

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We can link these adenovirus outbreaks in Japan. It was OP MindWars who first posted on the Mengla virus, but did not know its geography:

22 Feb 2019 A New Disturbing Ebola Related Virus Has Been Found in Bats in China
https://www.usmessageboard.com/thre...ebola-related-virus-has-been-found-in-bats-in china-known-as-the-filovirus-deadly.741110/
‘....8 Jan 2019....A professor at the Duke-Nus Medical School in Singapore....’

The adenovirus article in post #554 links to

1. Emerging Infectious Diseases Programme, Duke-NUS Medical School, Singapore

2. George Mason University, Manassas, Virginia

3. American University, Washington, D.C.

Mengla was found in Rousettus, the same genus that is reservoir for Marburg virus in Africa.

 

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A new disturbing ebola related virus has been found in bats in China known as the filovirus deadly

The Big Wobble: A new disturbing Ebola-related virus has been found in bats in China known as the filovirus or Mengla virus and can be deadly to humans Researchers have discovered a new Ebola-related virus in bats in China, a study says. The potentially dangerous filovirus, known as Mengla...

www.usmessageboard.com

 

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It was Bottlecap’s post #27 that linked the Obama-Biden administration for Duke-NUS funding:

15 Sep 2020 post #27:

Covid 19 news 9.14.2020. NY Post reports virus made in lab

This Virologist will be on FOX tonight... Looking forward to hear what it is she has to say.. I know MD's on both sides of this fence and I want to hear where the evidence is and what she has. She may be on fox but she has to stay hidden or die

www.usmessageboard.com

 

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Three principles have emerged:

1. Vaccines are still beating the variants.

2. The variants are pummeling unvaccinated people.

3. The longer principle No. 2 holds, the less likely No. 1 will hold.

The 3 Simple Rules That Underscore the Danger of Delta

Vaccines are still beating the variants, but the unvaccinated world is being pummeled.

www.theatlantic.com

 

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Highly contagious Delta in Australia is described in this report:

Delta variant of Covid leaves the world in chaos

As the Delta variant threatens a looming Covid-19 outbreak in New South Wales it seems Australia is not alone.

www.news.com.au

’....It’s a virus that is very capable of transmitting even when we have very fleeting proximity between the individual who is infectious and any of us who might be passing by.”

 

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Daszak of Eco Health Alliance and Z.L. Shi of Wuhan Institute of Virology co-authored the Mengla filovirus, which links back to 2015-16, which also links to Fauci at NIH:

Mengla Dianlovirus Isolate (Rousettus - wt/CHN/2015/Sharen-Bat 9447-1, complete genome)

Mengla dianlovirus isolate Rousettus-wt/CHN/2015/Sharen-Bat9447-1, com - Nucleotide - NCBI

’....Journal: submitted 1 Jun 2021, National Center for Biotechnology Information, NIH, Bethesda, Md.
....The reference sequence is identical to KX371887.
https://www.ncbi.nlm.nih.gov/nuccore/KX371887‘

Clicking on the KX371887 yields the Pubmed article:

Genetically Diverse Filoviruses in Rousettus and Eonycteris spp. Bats, China, 2009 and 2015 - PubMed

Genetically divergent filoviruses detected in Rousettus and Eonycteris spp. bats in China exhibited 61%-99% nt identity with reported filoviruses, based on partial replicase sequences, and they demonstrated lung tropism. Co-infection with 4 different filoviruses was found in 1 bat. These results...

pubmed.ncbi.nlm.nih.gov

’....Daszak P., Shi Z.L. Submitted 8 Jun 2016....Collection sites map: Mengla....Jinghong....We detected filofirus RNA in 15 fruit bat specimens (Eonycteris spelaea and Rousettus sp.)....5 samples contained filoviruses with more widespread tissue tropism....lung.’

As the chart shows, most of these filovirus-infected bats were infected in their lungs. The COVID-19 mutation D614G that Fauci flubbed in his video precisely links to ebola vaccine. Fauci knew about filoviruses infecting the lungs of Chinese bats as early as 2015-2016.