how to calculate the evolution of a protein

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That's amazing!

It's all pretty amazing.

 

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Was the first DNA strand fully formed and just waiting for its perfect protein Tinder match?

We don't know.

Here is a great database of interactions between amino acids and nucleotides.

AANT: the Amino Acid-Nucleotide Interaction Database - PubMed

We have created an Amino Acid-Nucleotide Interaction Database (AANT; http://aant.icmb.utexas. edu/) that categorizes all amino acid-nucleotide interactions from experimentally determined protein-nucleic acid structures, and provides users with a graphic interface for visualizing these...

pubmed.ncbi.nlm.nih.gov

There are mixed polymers, some of which are currently under investigation.

Here is more information:

https://chemistry-europe.onlinelibrary.wiley.com/doi/abs/10.1002/cbic.202200048