Be prepared for another lockdown

Why were the places in the sequence that should be manipulated for a more humanized and lethal virus, not?
 
So, keeping in mind that the virus already has experience with the California L452R mutation (one of the mutations of the Delta variant), someone working with California cases will compare the stats of those vaccinated with adenovirus-vectored vaccines (like the Russian and Chinese vaccines), to those stats for mRNA vaccines. The problematic is that the longer those who are unvaccinated remain so, the less safe the vaccinated will be.
 

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