Snake Meat......source of chinese virus

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We thought to search for serine-to-leucine mutations for clues about 2019-nCoV ORF8 (previous posts).

For now, we'll place two entries in the file, one because it's an ebola link, and the other because it resonates with EAV-tuberculosis (previous posts):

Borna Phosphorylation (Mononegavirales)
Protein kinase C-dependent phosphorylation of Borna disease virus P protein is required for efficient viral spread. - PubMed - NCBI

Codon usage by Bungarus was from the Ji et al study (previous posts).

Mycobacterium Codons 522 and 531
Enhanced heterogeneity of rpoB in Mycobacterium tuberculosis found at low pH. - PubMed - NCBI
 
China is Cremating Bodies in Secret

that-wasnt-chicken-16517363.png

~S~
 
AFT: Coronavirus Can Remain Infectious on Surfaces for 9 Days
BREAKING NEWS! New Research Reveals Coronavirus Can Remain Infectious For As Long As 9 Days On Surfaces! - Thailand Medical News

On the UW campus, they are now placing large bottles of antibacterial lotion near entrance doors. Hepatitis B virus can remain infectious on styrene surfaces for up to two weeks. Occasionally, badger2 works within 35 feet of a veterinary student, though there are no guarantees of any inside news from the vaccine lab.

Persistence of Coronavirus on Inanimate Surfaces and Its Inactivation with Biocidal Agents
'....62-71% ethanol, 0.5% hydrogen peroxide or 0.1% sodium hypochlorite inactivates within one minute.'
sciencedirect.com/science/article/pii/S0195670120300463
 
Fauci says (post #326) that remdesivir has shown promise: 'Dr. Anthony Fauci of National Institutes of Health said Friday that the antiviral drug remdesivir has shown positive results in fighting the coronavirus.'

Taking a closer look at other Thai meds used (successfully?) against 2019-nCoV (lopinavir), there is a link to melanoma:

Jan 2020 Jerusalem / Lopinavir / Melanoma
The integrated stress response promotes B7H6 expression. - PubMed - NCBI

However, this Serbian lopinavir report does not give the actual polymorphisms, only the rs numbers of the polymorphisms:
Influence of SLCO1B1 polymorphisms on lopinavir Ctrough inSerbian HIV/AIDS patients. - PubMed - NCBI
 
There is a report from South Africa for HIV and lopinavir for an asparagine to threonine mutation, linking at least three 2019-nCoV asparagines and one threonine on its genome:

South Africa / Lopinavir N37T Mutation
Drug susceptibility and replication capacity of a rare HIV-1 subtype C protease hinge region variant. - PubMed - NCBI
'....substitution of W1201-Gag with MJ4-Gag resulted in small but significant decrease in susceptibility to lopinavir and atazanavir (MJ4GagN37T)....Collectively, these data suggest that the N37T mutation and insertion increases viral infectivity and decreases drug susceptibility.'
 
Studying two of the 2019-nCoV meds used in Thailand, lopinavir (ABT-378) was developed by Abbott Laboratories in Illinois precisely because HIV-1 virus was mutating against ritonavir (ABT-538):

Lopinavir Developed from Ritonavir
ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. - PubMed - NCBI
'....The valine at position 82 (Val82) in the active site of HIV protease mutates in response to therapy with the protease inhibitor ritonavir. By using the X-ray crystal structure of the complex of HIV protease and ritonavir, the potent protease inhibitor, ABT-378, was designed. ABT-378 potently inhibited wild-type and mutant HIV protease....and maintained high potency against mutant HIV selected by ritonavir in vivo.'
 
Avian Flu Talk thread, Question: What is China Hiding and Why?, just began posting about 2019-nCoV/ACE2 13 hours ago. In that thread, a twitter feed suggests 1.5 million confirmed cases, 50,000 bodies incinerated. The chron in this thread at post #279, only adds two more cases since last night.
 
Pangolins are a really wonderful kind of anteater...…..probably people shouldn't eat them, though. What happened to the Mom rule? "Ask mom before you put anything in your mouth!"

I'm not totally sure I believe in pangolins --- there's sort of an inherent improbability about them.

pangolin-715x400.jpg
 
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