Scientists test way to stop heart damage after cardiac injury

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Scientists test way to stop heart damage after cardiac injury
September 28, 2017

The microscopic image on left shows a control mouse heart cross section after simulated cardiac injury with significant fibrosis. The image the right shows the "experimental model" in which Wnt/b-catenin was inhibited in the hearts of mice, …more

Early research results suggest scientists might be on to a way to preserve heart function after heart attacks or for people with inherited heart defects called congenital cardiomyopathies.
Researchers at the Cincinnati Children's Heart Institute report Sept. 28 in Nature Communications that after simulating heart injury in laboratory mouse models, they stopped or slowed cardiac fibrosis, organ enlargement and preserved heart function by blocking a well-known molecular pathway.

The Wnt/β-catenin signaling pathway is involved in several of the body's fundamental biological processes. After heart injury, however, Wnt/β-catenin signaling ramps up in cardiac fibroblast cells to cause fibrosis, scarring and harmful enlargement of the heart muscle, according to the researchers.
Scientists test way to stop heart damage after cardiac injury

It certainly would be nice for such science to be developed and used on patients in the future.
 

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