If she runs and wins in 2016, it would be a severe blow to the GOP.
I'd have to say I think the odds are against her, but the odds were against Obama getting re-elected and the Democrats gaining seats in both chambers in 2012.
I think the 2014 midterms are gonna be crucial for the GOP. If they lose seats, I fully expect them to trot out their planned to award EC electors by congressional districts in a few key states and get those legislatures to pass that in October of 2016.