Molnupiravir may be mutagenic in mammalian cells.
Aug 2021 Molnupiravir
pubmed.ncbi.nlm.nih.gov
As the 1973 Russian report by Andreeva, Poslovina, Salganic and Vasjunina stated, ‘the majority of mutants were proline- and arginine-deficient auxotrophs.’
2017 Wuhan University State Key Laboratory of Virology / Arginine Auxotrophic Tumors / Adenovirus
pubmed.ncbi.nlm.nih.gov
Aug 2021 Molnupiravir
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β-d-N4-hydroxycytidine Inhibits SARS-CoV-2 Through Lethal Mutagenesis But Is Also Mutagenic To Mammalian Cells - PubMed
Mutagenic ribonucleosides can act as broad-based antiviral agents. They are metabolized to the active ribonucleoside triphosphate form and concentrate in genomes of RNA viruses during viral replication. β-d-N4-hydroxycytidine (NHC, initial metabolite of molnupiravir) is >100-fold more active than …
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As the 1973 Russian report by Andreeva, Poslovina, Salganic and Vasjunina stated, ‘the majority of mutants were proline- and arginine-deficient auxotrophs.’
2017 Wuhan University State Key Laboratory of Virology / Arginine Auxotrophic Tumors / Adenovirus
![pubmed.ncbi.nlm.nih.gov](https://cdn.ncbi.nlm.nih.gov/pubmed/persistent/pubmed-meta-image-v2.jpg)
Arginine deiminase expressed in vivo, driven by human telomerase reverse transcriptase promoter, displays high hepatoma targeting and oncolytic efficiency - PubMed
Arginine starvation has the potential to selectively treat both primary tumor and (micro) metastatic tissue with very low side effects. Arginine deiminase (ADI; EC 3.5.3.6), an arginine-degrading enzyme, has been studied as a potential anti-tumor drug for the treatment of arginine-auxotrophic...
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