Cholesteral drug reduces Covid

[hadit]

gateway pundit is great for medical news!!!!

Did the researchers say it or not?

 

[badger2]

Transferrin and cholangiocarcinoma link to the cytokine, IL-6. IL-6 links to Alzheimer’s amyloid beta and increased ACE2 binding:

Transferrin / Cholangiocarcinoma / IL-6

Different iron-handling in inflamed small and large cholangiocytes and in small and large-duct type intrahepatic cholangiocarcinoma - PubMed

Cholangiocarcinoma (CCA) represents the second most common primary hepatic malignancy and originates from the neoplastic transformation of the biliary cells. The intrahepatic subtype includes two morpho-molecular forms: large-duct type intrahepatic CCA (iCCA) and small-duct type iCCA. Iron is...

pubmed.ncbi.nlm.nih.gov

Jul 2021 Taiwan / Abeta (1-42) / SARS-CoV-2 / IL-6

The Effects of Aβ1-42 Binding to the SARS-CoV-2 Spike Protein S1 Subunit and Angiotensin-Converting Enzyme 2 - PubMed

Increasing evidence suggests that elderly people with dementia are vulnerable to the development of severe coronavirus disease 2019 (COVID-19). In Alzheimer's disease (AD), the major form of dementia, β-amyloid (Aβ) levels in the blood are increased; however, the impact of elevated Aβ levels on...

pubmed.ncbi.nlm.nih.gov

’....Abeta (1-42) strengthened the binding of S1 of SARS-CoV-2 to ACE2 and increased viral entry and production of IL-6.’

 

[badger2]

Anti-COVID fenofibrate links to anti-Alzheimer’s fenofibrate:

Jun 2020 Germany / Fenofibrate / Nematode Paralysis Alzheimer’s Model

Amyloid-beta (Aβ1-42)-induced paralysis in Caenorhabditis elegans is reduced through NHR-49/PPARalpha - PubMed

Alzheimer´s disease is a neurodegenerative disorder characterized by the misfolding and aggregation of amyloid β (Aβ). Agonists of peroxisomal proliferator-activated receptors (PPARs) are discussed as anti-amyloidogenic compounds, e.g. due to their cholesterol-lowering activities. In a previous...

pubmed.ncbi.nlm.nih.gov

’....fenofibrate activates NHR49 and decreases the Alzheimer’s phenotype in CL2006....fenofibrate decreases Amyloid beta-induced paralysis in dependence on nhr-49 and nuclear translocation of DAF16.’

 

[occipitalgullet]

This is encouraging. We would be lost without science and innovation. Too bad there is such a war on science in the US right now. The Republican's solution: "thoughts and prayers". Religion has not cured a single thing. Ever.

 

[badger2]

Good info!

My question,

Is delta variant different? Now people hospitalized seem to be younger, less obese, fewer of these co-morbidities that affected people with the virus last year.... basically way younger and healthier??

Shortly, we’ll post the link to 137 Florida children.

 

[badger2]

9 Aug 2021 Florida Children

Children in Florida Increasingly Getting Sick With COVID As 172 in Hospital

The state has recorded record-breaking COVID figures multiple times over the past month, as the Delta variant continues to spread across the country.

www.newsweek.com

 

[badger2]

What has been mentioned thusfar linking fenofibrate adds to black fungus Mucor, and post-COVID diabetes:

11 Hours Ago India: Rise in Diabetes

Covid-19: Fears over sharp rise in diabetes in India

Doctors believe large numbers of recovered Covid patients are at risk of newly diagnosed diabetes.

www.bbc.com

 

[badger2]

Here is an SNP (single nucleotide polymorphism) that actually benefits diabetic treatments with fenofibrate-statins:

PPARalpha Polymorphism / Diabetes Type 2 / Cardiovascular Benefit (Boston, St. Louis, Harvard, Ontario, Alberta, Italy, New York, North Carolina, Seattle, NIH Maryland, Virginia)

PPARA Polymorphism Influences the Cardiovascular Benefit of Fenofibrate in Type 2 Diabetes: Findings From ACCORD-Lipid - PubMed

The cardiovascular benefits of fibrates have been shown to be heterogeneous and to depend on the presence of atherogenic dyslipidemia. We investigated whether genetic variability in the <i>PPARA</i> gene, coding for the pharmacological target of fibrates (PPAR-α), could be used to improve the...

pubmed.ncbi.nlm.nih.gov

’....If results of this study were brought into the clinic, they would translate into more than a doubling in the number of patients with T2D who would benefit from treatment with fenofibrate as add-on to statins.’

 

[badger2]

UK Researchers: Cheap Cholesterol Drug Reduces Covid-19 Infection by 70% | The Gateway Pundit | by Cristina Laila

A cheap drug that treats cholesterol reduces Covid infection by 70% in lab studies, according to a team of researchers in the UK.

www.thegatewaypundit.com

A drug that treats cholesterol reduces Covid infection by 70% in lab studies, according to a team of researchers in the UK.

The researchers published their findings in the Frontiers in Pharmacology journal on Friday.

Fenofibrate and fenofibric acid significantly reduced Covid infection in human cells so expect this affordable medication to be blacklisted soon.

“Our data indicates that fenofibrate may have the potential to reduce the severity of COVID-19 symptoms and also virus spread,” Dr. Elisa Vicenzi of the San Raffaele Scientific Institute in Milan and co-author, said in the release. “Given that fenofibrate is an oral drug which is very cheap and available worldwide, together with its extensive history of clinical use and its good safety profile, our data has global implications.”

Yup. It will be pushed under the rug because they insist on everone getting jabbed with their poison.

If SARS-CoV-2’s most ancient ancestor is the pig virus, PRRSV, then there is evidence that it too may be susceptible to cholesterol-lowering drugs. As we have recently learned, on this trajectory, Trump’s hydroxychloroquine is also exonerated:

2011 China: Ganglioside GM1 / PRRSV

Role of lipid rafts in porcine reproductive and respiratory syndrome virus infection in MARC-145 cells - PubMed

Lipid rafts play an important role in the life cycle of many viruses. Cholesterol is a critical structural component of lipid rafts. Although the porcine reproductive and respiratory syndrome virus (PRRSV) has restricted cell tropism for cells of the monocyte/macrophage lineage, a non-macrophage...

pubmed.ncbi.nlm.nih.gov

’....Inhibition of cholesterol synthesis inhibits PRRSV entry.’

The science that proves Trump was correct is here:

May 2020 France: SARS-CoV-2 / GM1 / Azithromycin / Hydroxychloroquine

Synergistic antiviral effect of hydroxychloroquine and azithromycin in combination against SARS-CoV-2: What molecular dynamics studies of virus-host interactions reveal - PubMed

The emergence of SARS-coronavirus-2 (SARS-CoV-2) has led to a global pandemic disease referred to as coronavirus disease 19 (COVID-19). Hydroxychloroquine (CLQ-OH)/azithromycin (ATM) combination therapy is currently being tested for the treatment of COVID-19, with promising results. However, the...

pubmed.ncbi.nlm.nih.gov

“Synergistic Antiviral Effect of Hydroxychloroquine and Azithromycin in Combination Against SARS-CoV-2: What Molecular Dynamics Studies of Virus-Host Interactions Reveal”
‘ATM (azithromycin) is directed against the virus, whereas CLQ-OH (hydroxychloroquine) is directed against cellular attachment cofactors. We conclude that both drugs act as competitive inhibitors of SARS-CoV-2 attachment to host cell membranes.’