Cholesteral drug reduces Covid

[Fort Fun Indiana]

They proved how evil they are when they blew up the Hydroxychloroquije plant as well.

HCQ does nothing for covid-19. Get over it. As it turns out, your cult leader - despite having zero knowledge about just about anything -- was wrong about it.

 

[badger2]

HCQ does nothing for covid-19. Get over it. As it turns out, your cult leader - despite having zero knowledge about just about anything -- was wrong about it.

Incorrect.

 

[Fort Fun Indiana]

Incorrect.

Then you also get to get sit in the corner with the alien abductees and the spoonbenders.

 

[Muhammed]

This has been watched for a while, and researchers have found that those with higher cholesterol and high blood pressure as a result as well, when prescribed any Statin to reduce their cholesterol level, they reduce their chances of getting really sick from covid by 40%.

It's not the drug itself that does it per say,

It's that these Statins reduce the cholesterol levels of those with high levels, and covid is spread in your body by attaching to cholesterol cells.... Less cholesterol cells, less rapid spread within you....IF I AM UNDERSTANDING IT CORRECTLY! And less high blood pressure, another high risk.

You are definitely not understanding it correctly. There's no such thing as a cholesterol cell.

 

[badger2]

Then you also get to get sit in the corner with the alien abductees and the spoonbenders.

USMB members are free to read Simone Gold’s paper behind your back, without you knowing who they are, dumbass.

 

[EvMetro]

I am talking about what it does in the real world.

How does that compare to its potential on paper or in specific optimum conditions in a lab?

 

[Care4all]

You are definitely not understanding it correctly. There's no such thing as a cholesterol cell.

Thank you! Could you explain it then, so a layman can understand?

 

[colfax_m]

How does that compare to its potential on paper or in specific optimum conditions in a lab?

Dunno, but I don’t find I terribly relevant because I’m not on paper or in a lab.

I’m in a real world situation where it works well.

 

[DudleySmith]

Sorry if this has already been posted as I don't have time to go through the thread at the moment, but ...

Frontiers | The Hyperlipidaemic Drug Fenofibrate Significantly Reduces Infection by SARS-CoV-2 in Cell Culture Models

The severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) pandemic has caused a significant number of fatalities and worldwide disruption. To identify...

www.frontiersin.org

"Fenofibrate has a relatively safe history of use, the most common adverse effects being abdominal pain, diarrhea, flatulence, nausea, and vomiting. The half-life of fenofibric acid is 20 h (Desager et al., 1996), allowing convenient once daily dosing. The recommended doses in the United Kingdom (up to 267 mg) provide plasma concentrations (Cmax 70 μM; Css 50 µM) comparable to those at which we and others have seen antiviral activity, Finally, if proven effective, fenofibrate is available as a “generic” drug and consequently is relatively cheap, making it accessible for use in all clinical settings, especially those in low and middle-income countries. Preliminary data indicate that fenofibrate is equally effective against the B.1.1.7 variant (data not shown) implying that mutations in S protein are unlikely to affect the efficacy of fenofibrate. There are a number of medical conditions which contraindicate the use of fenofibrate, such as significantly impaired kidney function, and these could potentially limit its use in the treatment of COVID patients. There are also a number of drug interactions with fenofibrate which are potentially severe, although some of these may be avoided by temporarily withholding the interacting drug. Appropriate risk-benefit analysis will be necessary once the clinical antiviral activity of fenofibrate is defined to identify which SRS-COV2 patients can safely be treated with fenofibrate. While further studies to clarify the precise mechanism of the antiviral activity of fenofibrate are ongoing, our data support the clinical evaluation of fenofibrate in the community infection setting and also in patients requiring hospitalization. One possibility is that fenofibrate is tested in newly diagnosed symptomatic patients, who do not require hospitalization, in whom reduction in viral infection levels by ...."

No mention of how much a daily dose would cost over 6 months versus a single booster shot; somebody said in another thread the Pfizer is around $19 or so per shot. It is off patent, though. I would bet that if 500 million people took it some would die, same as with any other 'magic bullet', and the conspiracy theorists would have to start assassinating each other.

Ah, well ...

Fenofibrate Prices, Coupons, Copay Cards & Patient Assistance - Drugs.com

Compare fenofibrate prices, print discount coupons, find manufacturer promotions, copay cards and patient assistance programs.

www.drugs.com

The cost for fenofibrate oral tablet 160 mg is around $36 for a supply of 30, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

So, it is far more expensive than the vaccines.

 

[badger2]

We cut to the chase: SARS-CoV-2’s closest relative comes from the Mojiang copper mine, Yunnan. The Large Spotted Civet, Viverra megaspila in Yunnan is a suspect reservoir of the virus. Opisthorchis viverrini is a parasite of civets. Starting with chloroquine, we track cholangiocarcinoma to Illinois:

1969 West Malaysia: Opisthorchis / Chloroquine

Opisthorchis viverrini (Poirier, 1886) a trematode parasite of man in West Malaysia - PubMed

Opisthorchis viverrini (Poirier, 1886) a trematode parasite of man in West Malaysia

pubmed.ncbi.nlm.nih.gov

Civet diet include molluscs.

Snail Intermediate Host
Fecal bacterial contamination in natural water reservoirs as an indicator of seasonal infection by Opisthorchis viverrini in snail intermediate hosts - PubMed

2012 Unarguable Cancer Risk Factor: Opisthorchis / Cholangiocarcinoma

The tumorigenic liver fluke Opisthorchis viverrini--multiple pathways to cancer - PubMed

Liver fluke infection caused by Opisthorchis viverrini is a major public health problem in Thailand and adjacent countries. In addition to infection-associated morbidity, infection with O. viverrini and the related Clonorchis sinensis are unarguable risk factors for cholangiocarcinoma (CAA...

pubmed.ncbi.nlm.nih.gov

Cholangiocarcinoma in the fruit bat, Rousettus aegyptiacus (a genus also found in Yunnan that was harboring a filovirus [ebola-Marburg family: Mengla virus]) includes iron storage disease:

https://pubmed.ncbi.nlm.nih/27010264

Illinois: First Reported Case Cholangiocarcinoma / COVID-19 / Thrombotic Microangiopathy / Gemcitabine

Thrombotic Microangiopathy in a Patient With COVID-19 Infection and Metastatic Cholangiocarcinoma - PubMed

This is a case report of a 63-year-old African American female with a past medical history most significant for metastatic cholangiocarcinoma that presented for evaluation of persistent shortness of breath. Initial workup was remarkable for refractory anemia, moderate schistocytes on peripheral...

pubmed.ncbi.nlm.nih.gov

When will the Communist Chinese start coughing up what they know about these phenomena in Yunnan?

 

[badger2]

Rousettus Cholangiocarcinoma

A RETROSPECTIVE STUDY OF THE LESIONS ASSOCIATED WITH IRON STORAGE DISEASE IN CAPTIVE EGYPTIAN FRUIT BATS (ROUSETTUS AEGYPTIACUS) - PubMed

Egyptian fruit bats (Rousettus aegyptiacus) are one of many species within zoologic collections that frequently develop iron storage disease. The goals of this retrospective multi-institutional study were to determine the tissue distribution of iron storage in captive adult Egyptian fruit bats...

pubmed.ncbi.nlm.nih.gov

The suspect civet also ranges into Vietnam, and the map we’ll post shows the river system in south Yunnan as well as the espressway system that connects Mojiang to Kunming, and further on in that direction, the expressway to Wuhan.

 

[EvMetro]

Dunno, but I don’t find I terribly relevant because I’m not on paper or in a lab.

I’m in a real world situation where it works well.

Why do you fight so hard to evade acknowledging that there is a difference between real world performance and potential performance? When you continuously evade this in each of our post exchanges, it shines a spotlight on it, and breeds suspicion that you are hiding something. Surely if you know so much about masks, you are aware that real world performance is not the same as potential performance. Surely you have had respirator fit tests done on you with banana oil in the tent, like those of us who are required to take ongoing hazmat training do when we requalify do, right?

 

[colfax_m]

Why do you fight so hard to evade acknowledging that there is a difference between real world performance and potential performance? When you continuously evade this in each of our post exchanges, it shines a spotlight on it, and breeds suspicion that you are hiding something. Surely if you know so much about masks, you are aware that real world performance is not the same as potential performance. Surely you have had respirator fit tests done on you with banana oil in the tent, like those of us who are required to take ongoing hazmat training do when we requalify do, right?

Isn’t there always a difference between potential and real world performance?

The thing you don’t want to talk about is that real world performance is good enough. I don’t know why you keep harping on something irrelevant.

 

[badger2]

Fenofibrate’s action includes PPAR alpha.

Oct 2020 New York; Maryland; Korea / SARS-CoV-2 / PPARalpha

Exercise as medicine for COVID-19: On PPAR with emerging pharmacotherapy - PubMed

Coronavirus disease 2019 (COVID-19) may have a metabolic origin given strong links with risk factors such as lipids and glucose and co-morbidities such as obesity and type 2 diabetes mellitus. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein mediates viral cellular...

pubmed.ncbi.nlm.nih.gov

’....cytoplasmic tail of this spike is heavily palmitoylated.’

India; Arabia. / Marine Terpenoid from Cacospongia / PPARgamma

Anti-COVID-19 terpenoid from marine sources: A docking, admet and molecular dynamics study - PubMed

Traditional medicines contain natural products (NPs) as main ingredient which always give new direction and paths to develop new advanced medicines. In the COVID-19 pandemic, NPs can be used or can help to find new compound against it. The SARS coronavirus-2 main protease (SARS CoV-2...

pubmed.ncbi.nlm.nih.gov

 

[EvMetro]

Isn’t there always a difference between potential and real world performance?

The thing you don’t want to talk about is that real world performance is good enough. I don’t know why you keep harping on something irrelevant.

Your reply to post 64 is why we are going around and around. That's where you showed that you were unwilling to differentiate real world vs on paper. You are STILL unwilling to acknowledge that there is a difference. I'm starting to see that you don't really know much about respirators and masks, and that you are just wearing what you are told to wear.

 

[colfax_m]

Your reply to post 64 is why we are going around and around. That's where you showed that you were unwilling to differentiate real world vs on paper. You are STILL unwilling to acknowledge that there is a difference. I'm starting to see that you don't really know much about respirators and masks, and that you are just wearing what you are told to wear.

There’s always a difference between lab capabilities and real world performance. Always.

I wear what I was told to wear and it worked. In a real world. What do you have to say about that?

 

[strollingbones]

Three things to know about the long-term side effects of COVID vaccines

Many Americans say they want to “make sure the shot is safe” before getting vaccinated. That data is already in, and it is overwhelming.

www.uab.edu

 

[badger2]

As one zooms out from Jinghong, one will see Mengla to the southeast. That is the site of the Mengla filovirus discovered in 2019 in Rousettus, a bat that’s second-most common cancer is cholangiocarcinoma. Mojiang, Tongguan, and expressways can be found on the map, and the river system goes into Vietnam. Following the river system north connects Dali City, one link to Eco Health Alliance, New York. This is Large-Spotted civet country.

Jinghong

Jinghong

Jinghong is the capital of Xishuangbanna in southern Yunnan. Jinghong has about 643,000 residents. Mapcarta, the open map.

mapcarta.com

 

[badger2]

Three things to know about the long-term side effects of COVID vaccines

Many Americans say they want to “make sure the shot is safe” before getting vaccinated. That data is already in, and it is overwhelming.

www.uab.edu

Thumbs up for the article. Again, “Long Covid” symptoms may include scratchy cough. Badger’s cleared up after rosuvastatin. Fenofibrate is used in conjunction with statins, so these meds may be indicated in future treatment for LC. C-19’s #1 target, elderly, #2 target, obesity.

 

[Care4all]

Fenofibrate’s action includes PPAR alpha.

Oct 2020 New York; Maryland; Korea / SARS-CoV-2 / PPARalpha

Exercise as medicine for COVID-19: On PPAR with emerging pharmacotherapy - PubMed

Coronavirus disease 2019 (COVID-19) may have a metabolic origin given strong links with risk factors such as lipids and glucose and co-morbidities such as obesity and type 2 diabetes mellitus. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein mediates viral cellular...

pubmed.ncbi.nlm.nih.gov

’....cytoplasmic tail of this spike is heavily palmitoylated.’

India; Arabia. / Marine Terpenoid from Cacospongia / PPARgamma

Anti-COVID-19 terpenoid from marine sources: A docking, admet and molecular dynamics study - PubMed

Traditional medicines contain natural products (NPs) as main ingredient which always give new direction and paths to develop new advanced medicines. In the COVID-19 pandemic, NPs can be used or can help to find new compound against it. The SARS coronavirus-2 main protease (SARS CoV-2...

pubmed.ncbi.nlm.nih.gov

Good info!

My question,

Is delta variant different? Now people hospitalized seem to be younger, less obese, fewer of these co-morbidities that affected people with the virus last year.... basically way younger and healthier??