Cancer Cures

[RodISHI]

I had an ulcer as a child that remain for years. I think that endometriosis was a gift from the ex-husband before he exited himself from our lives permanently. He died of Liver cancer a few years ago.

 

[RodISHI]

That's an important pathway for A. oxyphylla:

'Drug screen outcomes will require network or systems biology interpretation because some genes participate in multiple pathways, for example, phosphatidylinositol linases act in leukocyte extravasion and antigen pattern recognition pathways.'
(Schartl M, et al, Whole Body Melanoma Transcriptome Response in Medaka)

The Alpinia goes back fo the Persian Avicenna (Ibn Sina):

'Alpinia galana (Willd.), electuary; tumors of the stomach. Avicenna. Sontheimer, 1845. Heilmittel der Araber. Freiberg, Herder Verl. 288 pp.'
(Hartwell, Plants Used Against Cancer)

We're on the guess and by'goly program. My microscope is an oldie. Capable of checking the parasites locally that are invasive to the critters but not sufficient for much more than that. Dreams have along with the availability of reading through the studies on-line helped along the way as I sought for understanding some things.

 

[badger2]

That's a point: get your vit A by chewing the carrot, not drinking the juice.

Podophyllotoxin is found in other plants than May Apple:

'Podophyllotoxin occurs in conifers and in Berberid. Diphylleia grayi. Podophyllotoxin acetate occurs in Hernandi. Hernandia ovigera.'
(Gibbs, Chemotaxonomy of Flowering Plants)

'Alpinia. Rhizomoel; von A. galanga mit 5,6% Cineol, 2,6% Methylcinnamat und verschiedenen Sesquiterpenen uned Samenoel von A. galanga mit zwei neuen Phenylpropanen zwei Carryophyllenolen, Caryophyllenepoxid, n-Pentadecan und n' Heptadec-7-en.'
(Hegenauer, Chemotaxonomie der Pflanzen)

 

[badger2]

For hepatocellular carcinoma, there are two major viruses. Hepadnavirus is HBV, Flavivirus is HCV.

 

[badger2]

We are yet to zoom in on the actual geography where the compounds from Alpinia japonica could theoretically come into physical contact with the gills and eyes of the Japanese medaka, Oryzias latipes:

Alpinia japonica (Gardening in the Coastal Southeast)
southeastgarden.com/alpinia.html

 

[badger2]

So guess and b'golly, Alpinia exudates in the aquarium water. The trick would be to correlate circadian rhythm with the 90-minute time-window for MeWo cells and the medaka tumor, adjusting for the temperature deficit twixt fish and humans.

 

[badger2]

'Agarofuranderivate und weitere Sesquiterpenoide aud Rhizomoel von Alpinia japonica. Cineol, alph-Humulen, Farnesen, Farnesol und Zimtaldehyd in samenoel von A. katsumadai. Genaue Analyse des Rhizomoels von A. officinarum; 46 neue Komponenten. Nootkatol aus Fruechte von A. oxyphylla. Im Oel von Blatt und Stengel von A. speciosa viel Cineol und 4-Terpineol oder Limonen, Camphen, Campher und Methylcinnamat _ Cinnamylacetat nachgewiesen; offensichtlich existieren von dieser Sippe verschiedene Chemodeme.'
(Hegenauer, op cit)

 

[badger2]

'Amomum cardamom L. plaster (induration o9f the liver); poultice ( induration of the uterus); Reichenau Antiodotarium, 9-10 century.

Amomum costatum Benth. & Hook f. cancer of the uterus; all 3 patients "cured", China (Lu, C.C. 1960 Studies on the Treatment of Uterine Cancer, J. Chin. Med. (Peling) 6: 396-7).'

 

[RodISHI]

Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism.
Menadione (vitamin K) enhances the antibiotic activity of drugs by cell membrane permeabilization mechanism. - PubMed - NCBI


VITAMIN K SUBSTANCES
https://monographs.iarc.fr/ENG/Monographs/vol76/mono76-16.pdf

 

[badger2]

Yes, permeability of mitochondria will figure onto cancer trajectories.

Last post for today, we note that it's been a stellar day for Alpinia. Its constituent, caryophyllene is up for further investigations in breast cancer, and we also have more from Hegenauer for zerumbone. Note the daucanes for chewed carrots (mixed with saliva, rather than drinking the juice):

Caryophyllene / Acarbose
Natural product driven diversity via skeletal remodeling of caryophyllene β-lactam. - PubMed - NCBI

Zerumbone / Daucanes
New drugs from old natural compounds: scarcely investigated sesquiterpenes as new possible therapeutic agents. - PubMed - NCBI

Acarbose / Insulin Levels in Breast Cancer
Diazoxide for Lowering Insulin Levels in Breast Cancer Patients. - PubMed - NCBI

 

[badger2]

Mitochondria permeability links zerumbone, as Gibbs states 'Zingiber zerumbet (rhiz.) zerumbone.' (Chemotaxonomy of Flowering Plants)

Zingiberales
Zingiberales - Wikipedia
'....The order, which has a fossil record, is thought to have originated in the early Cretaceous period 90-120 million years ago (Mya), most likely in Australia.'

Zerumbone Inhibits Melanoma Cell Proliferation and Migration by Altering Mitochondrial Functions
Zerumbone inhibits melanoma cell proliferation and migration by altering mitochondrial functions. - PubMed - NCBI

 

[badger2]

For sciatic nerve mentioned in this thread, there is a cold and allodynia link:

Sciatic Nerve / Cold / Allodynia
Comparison of the effects of curcumin, tramadol and surgical treatments on neuropathic pain induced by chronic constriction injury in rat. - PubMed - NCBI

We link cannabis oil via prophylaxis in countering the chemotherapy effects of paclitaxel. Basically, paclitaxel is taxol. As will be shown later, taxol will link to Alpinia B-ring chemistry.

Prophylatic Cannabinoid / Paclitaxel (Taxol)
Prophylactic cannabinoid administration blocks the development of paclitaxel-induced neuropathic nociception during analgesic treatment and followi... - PubMed - NCBI

'The story of taxol, a molecule that received much publicity in the early 1990s, goes back to ancient times. Julius Caesar mentions in his "Gallic Wars" that Catuvolcus, a chieftain of the Eburones, committed suicide by taking extracts from the yew tree. Several other accounts report more recent uses of such extracts as poison or as a cancer-healing folk medicine....the eight-membered ring has traditionally been regarded as one of the most difficult to construct, and the development of general methods for its synthesis has received a great deal of attentioin. Thbe powerful combination of the eight-membered ring and the array of oxygenated functionality decorating the periphery of the molecule make taxol an extremely challenging target for synthesis.
....
Although the yield for the crucial cyclization step was modest (23% yield), it was encouraging that the congested taxane carbon framework could be assembled through
direct closure of the eight-membered B-ring....With an adequate solution to the B-ring problem, the unresolved issues associated with ring C can now be addressed. Intermediate 6, containing an appropriately placed double bond, seems poised for the requisite oxetane annulation.'
(Nicolaou KC, Taxol, in Classics in Total Synthesis)

'We may note: Zingiberaceae show, in at least one member of the family, Alpinia japonica, what may well prove to be a family character, the possession of flavonoids unsubstituted in the B-ring.'
(Gibbs, Chemotaxonomy of Flowering Plants)

 

[badger2]

Vitamin K for permeability may be contraindicated in cancers due to angiogenesis, but more likely due to reactive oxygen species (ROS):

Depression / Mitochondrial Pore Sealing / Alpha-Tocopherol
Venlafaxine-Induced Cytotoxicity Towards Isolated Rat Hepatocytes Involves Oxidative Stress and Mitochondrial/Lysosomal Dysfunction. - PubMed - NCBI

 

[badger2]

Two types of angiogenesis: gynecological, whereby endothelial cells migrate in the gravid female, and angiogenesis produced by cancer cells. Metastatic melanoma can mean escape from the primary site to invade endothelial cells and thus into the bloodstream, a more dangerous migration.

 

[RodISHI]

Mangoes a new fruit to be added to our diet frequently. I had no clue how good they are for you until getting a couple a few days ago. They were on sale because of being at the point of no return if not eaten or canned. So bought, cooked and made into something similar to Peach Butter. Haven't done anything yet with the skins or pits that are shaped something like Oysters (Mango butter for skin possibly). The skins have a lovely faint Cedar scent to them.

Mangifera Indica (Mango)

SUMMARY
Mangifera indica (MI), also known as mango, aam, it has been an important herb in the Ayurvedic and indigenous medical systems for over 4000 years. Mangoes belong to genus Mangifera which consists of about 30 species of tropical fruiting trees in the flowering plant family Anacardiaceae. According to ayurveda, varied medicinal properties are attributed to different parts of mango tree. Mango possesses antidiabetic, anti-oxidant, anti-viral, cardiotonic, hypotensive, anti-inflammatory properties. Various effects like antibacterial, anti fungal, anthelmintic, anti parasitic, anti tumor, anti HIV, antibone resorption, antispasmodic, antipyretic, antidiarrhoeal, antiallergic, immunomodulation, hypolipidemic, anti microbial, hepatoprotective, gastroprotective have also been studied. Pharmacologically and medicinally important chemical such as mangiferin, being a polyphenolic antioxidant and a glucosyl xanthone, it has strong antioxidant, anti lipid peroxidation, immunomodulation, cardiotonic, hypotensive, wound healing, antidegenerative and antidiabetic activities.

Antimicrobial Activities of Seed Extracts of Mango (Mangifera indica L.) Antimicrobial Activities of Seed Extracts of Mango (Mangifera indica L.)
Amgad A. Awad El-Gied, Martin R. P. Joseph, Ismail M. Mahmoud, Abdelkareem M. Abdelkareem, Ahmad M. Al Hakami, Mohamed E. Hamid
Affiliation(s)

Department of Clinical Microbiology and Parasitology, College of Medicine, King Khalid University, Abha, KSA.
Department of Pharmaceutics, College of Pharmacy, King Khalid University, Abha, KSA.
Department of Pharmaceutics, College of Pharmacy, Omdurman Islamic University, Omdurman, Sudan.
ABSTRACT

Mangifera indica L. is a species of mango in the Anacardiaceae family. It is found in the wild in tropical regions and cultivated varieties have been introduced to other warm regions of the world. This present study aimed to investigate the in vitro antimicrobial activities of methanol and ethanol extracts of mango seed against 25 representatives gram positive, gram negative, acid fast bacteria and fungi. Mango fruit seed were extracted by Soxhlet using methanol and ethanol as solvents. The extracts were tested against the microorganisms using disc diffusion method at different concentrations: 5 mg/mL, 3.75 mg/mL, 3.125 mg/mL, 2.5 mg/mL, 1.875 mg/mL and 1.25 mg/mL). In vitro antibacterial activities of methanol and ethanol extracts of mango bulb showed inhibitions to tested organisms with variable inhibition zones. Except one organism (Rhodococcus equi), no resistance among the tested strains was shown. The mean zone of inhibition produced ranged between 5 mmand18 mmwith18 mm/Mycobacterium smegmatis showed the highest zone of inhibition. In most test strains comparable zones of inhibitions were noted for both methanol and ethanol extract. Candida albicans and Aspergilllus niger were both inhibited by the extracts. The methanol and ethanol extracts of mango seed showed good inhibitory effects against almost all tested strains. The inhibition zones produced by mango extract were less than those produced by standard positive control drug. This could be due to low diffusion rate of mango extract in agarose medium, a thing needed to be further investigated. The products are potential new antimicrobial therapy in the ethnopharmacology domain.
Full http://file.scirp.org/pdf/AiM_2012122816551325.pdf

 

[badger2]

We have already mentioned the NF-kappaB link between hepatitis B virus and melanoma in this thread.

Egypt: Mangiferin / NF-KappaB
Mangiferin protects against. - PubMed - NCBI

 

[RodISHI]

We have already mentioned the NF-kappaB link between hepatitis B virus and melanoma in this thread.

Egypt: Mangiferin / NF-KappaB
Mangiferin protects against. - PubMed - NCBI

Its the first time I had ever eaten one and that link I put in tells about all the other cool attributes it has.

 

[badger2]

Astonishingly, there is only one entry for cancer:

'Mangifera indica L. nut-shell juice for warts, Brazil (de Martius C.F.P. 1843 Systema Materiae Medicae Vegitabilis Brasiliensis. Leipzig and Vienna 155 pp.).'
(Hartwell, Plants Used Against Cancer)

 

[badger2]

We suspect that the nut-shell juice's active constituent is a tannin, though increased ROS (reactive oxygen species) could likely assist melanoma growth:

Mangifera / Breast Cancer / Increased ROS / MTOR Pathway
Polyphenolics from mango (Mangifera indica L.) suppress breast cancer ductal carcinoma in situ proliferation through activation of AMPK pathway and... - PubMed - NCBI

Mangifera / Pancreatic Cancer
Chemical Constituents of Mangifera indica and Their Antiausterity Activity against the PANC-1 Human Pancreatic Cancer Cell Line. - PubMed - NCBI

 

[badger2]

Melanoma and Sunspots

'As evidence for this relationship, Houghton and colleagues (Increased Incidence of Malignant Melanoma After Peaks of Sunspot Activity, The Lancet [1978] i: 750-60) cite a correlation between melanoma incidence and sunspot activity.'
(Medical Oncology, Ch. 21 Melanoma)

Whooping Cranes
Are whooping cranes destined for extinction? Climate change imperils recruitment and population growth. - PubMed - NCBI
'....Years with fewer sunspots indicated greater recruitment.'