This is survival. You must die before others. Get your guns people. Load up on ammo. They will keep laughing.You can believe whatever you want about me, but don't make statements about me not giving my credentials if you aren't going to believe what I say anyway. It's fruitless. I expect that the content of my posts would be able to demonstrate I know what I'm talking about.This is the internet and we are left with taking your word for it that you are a physician. That caveat aside, (along with some others), your link suggests not quite "zero effect" if I understand this excerpt correctly;Aren't you letting politics trump science on these issues? It sure seems like it to me. People need to step back and take a look at the whole body of evidence and the strengths of each piece in order to make an assessment. You don't pick a side and then find papers to support it, you only pick a side after a critical evaluation of the evidence.Because as we too often see, politics tends to trump science on these issues, such as we see in the "environmentalist" agenda of the Left regards the pseudo-science of ACC/AGW.Socialist agenda? WTF does that have to do with it?Thanks for showing either your lack of reading comprehension of adherence to your socialist agenda.
The paper quoted is yet another observational study. Garbage in. Garbage out.
Your claim of GIGO is one of personal and subjective opinion, not an objective one, and comes from you political bias perspective. Note you provide no credentials in your Profile on this forum yet claim to be a superior judge of science, even though presented with numerous sources from science and medical journals. I suggest that if there is any GIGO, it is from you!
As far as I'm aware, not a single randomized trial has ever shown any benefit to hydroxychloroquine or zinc. For example here:
Zero effect.Effect of Zinc and Ascorbic Acid on Symptom Length Among Patients With SARS-CoV-2
This randomized clinical trial examines whether high-dose zinc and/or high-dose ascorbic acid reduces the severity or duration of symptoms compared with usual care among ambulatory patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.jamanetwork.com
The sources just aren't of a sufficient quality or quantity to outweigh the large amount of data that is against the use of hydroxychloroquine. I'm a physician, I've been critically evaluating medical literature my entire career and spent the better part of 14 years of formalized post-secondary education learning how to do so. What you don't do, is you don't pick a paper and wave it around saying it makes you right and ignore everything else. That's just not how it works. You don't chose observational studies over prospective randomized trials. It just doesn't work that way.
I had no problem with hydroxychloroquine. I use it for other indications on occasion. I'm familiar with it. I'm not scared of it. I consider it a very benign drug. We used it in our hospital early in the pandemic, routinely. I had no problem giving it a shot. But when the data didn't provide evidence of it's efficacy, we moved on. What Trump did or didn't say had nothing to do with it.
" ... Patients who received usual care without supplementation achieved a 50% reduction in symptoms at a mean (SD) of 6.7 (4.4) days compared with 5.5 (3.7) days for the ascorbic acid group, 5.9 (4.9) days for the zinc gluconate group, and 5.5 (3.4) days for the group receiving both (overall P = .45). There was no significant difference in secondary outcomes among the treatment groups. "
...
~~~~~~~~Effect of Zinc and Ascorbic Acid on Symptom Length Among Patients With SARS-CoV-2
This randomized clinical trial examines whether high-dose zinc and/or high-dose ascorbic acid reduces the severity or duration of symptoms compared with usual care among ambulatory patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.jamanetwork.com
6.7 vs 5.9 would suggest something in the range of @20% +/- difference (improvement) by my math. That would seem significant of there is close to a day difference, gain.
Case in point, your idea that there isn't a "zero effect". Note the P value of 0.45. It's not significant. There is a high chance that the difference between the groups is due to random chance alone. This is why we aim for lower P values, usually 0.05 which indicates that there is a 5% or less chance that the difference is due to chance. There's far too much overlap in the 95% confidence intervals in these groups.