Hydroxychloroquine as treatment for COVID-19 shows no benefit and more deaths in VA study

[Fort Fun Indiana]

I did.

Then you know he provided zero useful information.

 

[Death-Ninja]

So many other studies found it helpful. I wonder what happened?

They really didn't. There was lots of irresponsible, anecdotal bragging by a very few professionals and some "testimonials". Not good evidence. And what is happening now is that better studies are being done, and it's not looking good.

You are completely full of shit, its one thing for you to be clinically imbecilic, and another entirely to just wander about thread to thread and lying lips off! The VA study was just thoroughly discredited by the French expert who compiled the most respected study of the anti-malarial most medical professionals cite as source of inspiration for prescribing Hydroxychloroquine. His study demonstrated 91% effectiveness in treating Wuhan flu, it is also the study which identified a greater effectiveness early on in infection, and less effectiveness late into infection!

You are the irresponsible asshole, deliberately endeavoring to induce panic, and or despair in people, probably for no greater purpose than to entertain yourself! Again, folks this creature is an asshole, and completely full of shit, the so-called VA study bearded for by radically untrustworthy AP and all other leftists in media, has been expertly debunked as ridiculously flawed, and that is that! Folks, you need to see these assholes for just what they are, deeply psychopathic ideologues who either labor directly on behalf of fascists such as the democratic party, or as with the above imbecile, simply to entertain themselves!

 

[Fort Fun Indiana]

The VA study was just thoroughly discredited by the French expert

Hah...no it wasn't. You are insane.

 

[BWK]

It's been used successfully since 1955. If it was killing people we would have known long before this.

No you wouldn't, because long before this, people didn't have Coronavirus. How can people be this stupid?

Ohhh so hydroxychloroquine only kills people that have Chinese virus. Do you have ANY idea how silly and ignorant that sounds? Any idea at all??

Making shit up out of thin air is not a recipe for debate. Try again.

 

[BWK]

About 28% who were given hydroxychloroquine plus usual care died, versus 11% of those getting routine care alone. About 22% of those getting the drug plus azithromycin died, too, but the difference between that group and those receiving usual care was not considered large enough to rule out other factors that could have affected survival.
snip
Researchers did not track side effects but noted hints that hydroxychloroquine might have damaged other organs. The drug has long been known to have potentially serious side effects, including altering the heartbeat in a way that could lead to sudden death.

Hydroxychloroquine as treatment for COVID-19 shows no benefit and more deaths in VA study

President Trump has frequently touted the malaria drug as a potential breakthrough in the ongoing coronavirus fight.

www.marketwatch.com

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But its not peer reviewed. Facts are facts, tramp should of never recommended it for days and days endless times, he quit talking about it a few days ago, I wonder why??

There has not been a clinical study completed yet. So, I sus[ect you are either citing comments by Trump-haters who only want to denounce HCQ because mean old Trump mentioned it.

Or, you are citing comments by someone associated with big pharma, and no one will get rich producing HQC, since it's been around 60 years and cost five cents per pill to make.

If there hasn't been a completed clinical study, why in the fuck would you put it on the market? That's insane.

Because it is used to treat other things.

Exactly! Thank you! For "other things." Those are the two key words. It's on the market for "other things', just not Covid-19.

No one said it was just used for COVID 19

So what is your point then? My point is that it hasn't been through any clinical trials.

 

[Death-Ninja]

The VA study was just thoroughly discredited by the French expert

Hah...no it wasn't. You are insane.

Folks, see how the low IQ never provides anything in way of cite? It's sole purpose is simply to disinform, and provoke conflict, you must always demand such imbeciles provide evidence, such as citing relevant expert evidence, or in this instance the study itself, which currently is being bearded by drudge and other deeply untrustworthy leftist sources, all of whom pursue Marxist agendas or hate the president... by the way, here's the twitter to the French expert who outed the study these wankers are bearding for, he savages it as "scientific fraud!

Didier Raoult (@raoult_didier) | Twitter

The latest Tweets from Didier Raoult (@raoult_didier). Directeur de l'IHU Méditerranée Infection. Professeur de médecine. Infectiologue. Microbiologiste

twitter.com

 

[TemplarKormac]

But its not peer reviewed.

Ah, but here's something that is. Try reading actual science, moron.

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Response-to-Magagnoli.pdf

 

[TemplarKormac]

The VA study was just thoroughly discredited by the French expert

Hah...no it wasn't. You are insane.

Hah! Yes it was!

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Response-to-Magagnoli.pdf

 

[BWK]

The VA study was just thoroughly discredited by the French expert

Hah...no it wasn't. You are insane.

Hah! Yes it was!

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Response-to-Magagnoli.pdf

The article you present, does not present to us finality from any clinical trial that yields a successful outcome in the fight against COVID-19. Therefore, the publication shows us nothing relevant. It does not zero in on any cure. It just presents different biases. And? What about them?

 

[TemplarKormac]

The VA study was just thoroughly discredited by the French expert

Hah...no it wasn't. You are insane.

Hah! Yes it was!

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Response-to-Magagnoli.pdf

The article you present, does not present to us finality from any clinical trial that yields a successful outcome in the fight against COVID-19. Therefore, the publication shows us nothing relevant. It does not zero in on any cure. It just presents different biases. And? What about them?

It comes from the man who actually did trials on COVID patients using Hydroxychloroquine: Dr. Didier Raoult.

My oh my.

Need another shovel there, mate?

 

[BWK]

The VA study was just thoroughly discredited by the French expert

Hah...no it wasn't. You are insane.

Hah! Yes it was!

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Response-to-Magagnoli.pdf

The article you present, does not present to us finality from any clinical trial that yields a successful outcome in the fight against COVID-19. Therefore, the publication shows us nothing relevant. It does not zero in on any cure. It just presents different biases. And? What about them?

It comes from the man who actually did trials on COVID patients using Hydroxychloroquine.

Dr. Didier Raoult.

My oh my.

Need another shovel there, mate?

No, the one I have is fine. Yours seems to need a new point on it though, because you aren't making a point with your link. The fact that someone is testing Covid patients with the drug is great. And? Have they tested every possible patient with every possible other condition those patients might be experiencing besides Covid, to go along with the virus? We are still trying to figure out where your shovel is going with this? Make a point, not a riddle.

 

[TemplarKormac]

The fact that someone is testing Covid patients with the drug is great. And?

My, aren't you uninformed. Dr. Didier Raoult was one of the first scientists in the world to test the efficacy of HCQ on COVID-19 patients. Here, let me pull the abstract for you:

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Abstract_Raoult_EarlyTrtCovid19_09042020_vD1v.pdf

And the corresponding Patient Table:

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Table_final_website_IHU_09_04_2020.pdf

 

[BWK]

Your emoji laugh tells us everything we need to know. Your link is saying absolutely nothing yielding no value whatsoever. A guy doing some testing. And? Lol!

 

[TemplarKormac]

Have they tested every possible patient with every possible other condition those patients might be experiencing besides Covid, to go along with the virus?

If you had read Dr. Raoult's study, you would know that he tested 1061 patients with COVID-19 and numerous patients with contraindications.

 

[TemplarKormac]

Your emoji laugh tells us everything we need to know. Your link is saying absolutely nothing yielding no value whatsoever. A guy doing some testing. And? Lol!

Want more? Your dismissive attitude shows you have very little to argue.

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial - PubMed

Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.

www.ncbi.nlm.nih.gov

 

[TemplarKormac]

Your emoji laugh tells us everything we need to know. Your link is saying absolutely nothing yielding no value whatsoever.

I posted the actual study, and the corresponding table. If you had bothered to read it.

 

[BWK]

The fact that someone is testing Covid patients with the drug is great. And?

My, aren't you uninformed. Dr. Didier Raoult was one of the first scientists in the world to test the efficacy of HCQ on COVID-19 patients. Here, let me pull the abstract for you:

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Abstract_Raoult_EarlyTrtCovid19_09042020_vD1v.pdf

And the corresponding Patient Table:

https://www.mediterranee-infection.com/wp-content/uploads/2020/04/Table_final_website_IHU_09_04_2020.pdf

You know, it doesn't take long to discredit that which has not been proven to be a final product. Among this group, 25 patients are now cured and 16 are still hospitalized (98% of patients cured so far). Poor clinical outcome was significantly associated to older age (OR 1.11), initial higher severity (OR 10.05) and low Do they know the exact age cut off? How are the 16 who are still hospitalized? Do you know? Do we know? No! Keep at it. And remember one thing, while your promoting your new found drug, most young patients recover without any treatment. Doesn't appear the drug does to well with old patients though. Keep trying.

 

[BWK]

Your emoji laugh tells us everything we need to know. Your link is saying absolutely nothing yielding no value whatsoever. A guy doing some testing. And? Lol!

Want more? Your dismissive attitude shows you have very little to argue.

Hydroxychloroquine and azithromycin as a treatment of COVID-19: results of an open-label non-randomized clinical trial - PubMed

Despite its small sample size, our survey shows that hydroxychloroquine treatment is significantly associated with viral load reduction/disappearance in COVID-19 patients and its effect is reinforced by azithromycin.

www.ncbi.nlm.nih.gov

Please, indulge me with that which has not been proven. Can't wait. What you fail to understand, is that there is a relationship between a drug, and the various conditions of the patient such as asthma, heart disease, diabetes, obesity, thyroid conditions, etc. Has the drug cured all these type patients at all ages? That's the question they need to have answers for. Are there side effects for those with medical conditions? What your publications are revealing to us is this, it's a work in progress. No more. Tell them to keep at it.

 

[TemplarKormac]

You know, it doesn't take long to discredit that which has not been proven to be a final product. Among this group, 25 patients are now cured and 16 are still hospitalized (98% of patients cured so far). Poor clinical outcome was significantly associated to older age (OR 1.11), initial higher severity (OR 10.05) and low Do they know the exact age cut off? How are the 16 who are still hospitalized? Do you know? Do we know? No! Keep at it. And remember one thing, while your promoting your new found drug, most young patients recover without any treatment. Doesn't appear the drug does to well with old patients though. Keep trying.

Hah.

Sure.

Coming from someone who demands absolute perfection from studies he apparently doesn't read through.

"Huang et al. reported the clinical features and cytokine profile of critically ill patients with COVID-19 in Wuhan, China, and suggested that a cytokine storm (i.e. higher concentrations of granulocyte-colony stimulating factor, interferon gamma-induced protein 10, monocyte chemoattractant protein 1, macrophage inflammatory protein 1α and tumour necrosis factor α) could be associated with the severity of disease."

"Recently, chloroquine and its derivative hydroxychloroquine have been used in the treatment of COVID-19. In February 2020, results from more than 100 Chinese patients with COVID-19 showed that chloroquine phosphate had good efficacy [8]. French doctors conducted an open-label non-randomized clinical trial, and 20 patients with COVID-19 who received hydroxychloroquine treatment showed good efficacy [9]. Both chloroquine and hydroxychloroquine are weak bases and are able to accumulate in acidic organelles (e.g. lysosomes); as such, they can increase endosomal/lysosomal pH and inhibit viral replication [10]. In addition to their antimalarial and antiviral effects, their anti-inflammatory properties have been demonstrated in the treatment of autoimmune diseases such as rheumatoid arthritis and lupus erythematosus. Chloroquine and hydroxychloroquine can inhibit major histocompatibility complex class II expression, antigen presentation and immune activation (reducing CD154 expression by T cells) via Toll-like receptor signalling and cGAS stimulation of interferon genes [11]. Thus, chloroquine and hydroxychloroquine can reduce the production of various pro-inflammatory cytokines, such as IL-1, IL-6, interferon-α and tumour necrosis factor, which are involved in the cytokine storm [11]. These immunomodulatory effects synergize their antiviral effects in the treatment of COVID-19.

Immunomodulatory agents that directly target the key cytokines involved in COVID-19 may also help to alleviate hyperinflammation symptoms in severe cases [12]. Elevated levels of the inflammatory indicator IL-6 in the blood have been reported to be predictive of a fatal outcome in patients with COVID-19 [13]. Tocilizumab, a specific monoclonal antibody that blocks IL-6, has been recommended for use in severe or critically ill patients with extensive lesions in bilateral lungs and a confirmed elevated level of IL-6 in the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7) issued by the National Health Commission of China [7]. A retrospective analysis on 20 severe cases of COVID-10 showed that treatment with tocilizumab led to a reduction in fever and lung lesion opacity, and recovered the percentage of lymphocytes in peripheral blood [14]."

Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies

www.ncbi.nlm.nih.gov

 

[BWK]

You know, it doesn't take long to discredit that which has not been proven to be a final product. Among this group, 25 patients are now cured and 16 are still hospitalized (98% of patients cured so far). Poor clinical outcome was significantly associated to older age (OR 1.11), initial higher severity (OR 10.05) and low Do they know the exact age cut off? How are the 16 who are still hospitalized? Do you know? Do we know? No! Keep at it. And remember one thing, while your promoting your new found drug, most young patients recover without any treatment. Doesn't appear the drug does to well with old patients though. Keep trying.

Hah.

Sure.

Coming from someone who demands absolute perfection from studies he apparently doesn't read through.

"Huang et al. reported the clinical features and cytokine profile of critically ill patients with COVID-19 in Wuhan, China, and suggested that a cytokine storm (i.e. higher concentrations of granulocyte-colony stimulating factor, interferon gamma-induced protein 10, monocyte chemoattractant protein 1, macrophage inflammatory protein 1α and tumour necrosis factor α) could be associated with the severity of disease."

Recently, chloroquine and its derivative hydroxychloroquine have been used in the treatment of COVID-19. In February 2020, results from more than 100 Chinese patients with COVID-19 showed that chloroquine phosphate had good efficacy [8]. French doctors conducted an open-label non-randomized clinical trial, and 20 patients with COVID-19 who received hydroxychloroquine treatment showed good efficacy [9]. Both chloroquine and hydroxychloroquine are weak bases and are able to accumulate in acidic organelles (e.g. lysosomes); as such, they can increase endosomal/lysosomal pH and inhibit viral replication [10]. In addition to their antimalarial and antiviral effects, their anti-inflammatory properties have been demonstrated in the treatment of autoimmune diseases such as rheumatoid arthritis and lupus erythematosus. Chloroquine and hydroxychloroquine can inhibit major histocompatibility complex class II expression, antigen presentation and immune activation (reducing CD154 expression by T cells) via Toll-like receptor signalling and cGAS stimulation of interferon genes [11]. Thus, chloroquine and hydroxychloroquine can reduce the production of various pro-inflammatory cytokines, such as IL-1, IL-6, interferon-α and tumour necrosis factor, which are involved in the cytokine storm [11]. These immunomodulatory effects synergize their antiviral effects in the treatment of COVID-19.

Immunomodulatory agents that directly target the key cytokines involved in COVID-19 may also help to alleviate hyperinflammation symptoms in severe cases [12]. Elevated levels of the inflammatory indicator IL-6 in the blood have been reported to be predictive of a fatal outcome in patients with COVID-19 [13]. Tocilizumab, a specific monoclonal antibody that blocks IL-6, has been recommended for use in severe or critically ill patients with extensive lesions in bilateral lungs and a confirmed elevated level of IL-6 in the Diagnosis and Treatment Protocol for Novel Coronavirus Pneumonia (Trial Version 7) issued by the National Health Commission of China [7]. A retrospective analysis on 20 severe cases of COVID-10 showed that treatment with tocilizumab led to a reduction in fever and lung lesion opacity, and recovered the percentage of lymphocytes in peripheral blood [14].

Cytokine storm and immunomodulatory therapy in COVID-19: Role of chloroquine and anti-IL-6 monoclonal antibodies

www.ncbi.nlm.nih.gov

Already read up on all that bud. And you aren't telling us anything more than you did in the beginning or what we didn't already know. You are promoting a work in process as a finished product. Sorry, it doesn't work that way. Not everyone responds positively in the same way. That is the hoop you have to jump over.