Work for what? You'd have to drink it to feel the effects of the acid.
Inhaling the vapor wouldn't do it?
It might. The first trip of the scientist who first extracted it had it absorbed through his skin. I'm not sure what the evaporation point of LSD is, but I think spiking the bong water with it would be a waste of LSD. Better to spike your OJ and make some Orange Sunshine.
LSD in bong water wouldn't be the best way to gauge a dosage. A normal hit of LSD is between 90-150 micro-grams....which is the next thing to nothing....hard to measure a dosage like that in bong water. The heavy hitters would cap out at around 700 micro-grams, still very small amount to measure.....or so I've been told.